Discovery Chemistry Services

SteerOn offers Integrated Discovery Chemistry Services helping clients to fast tract their IND submission

Computational
Chemistry

Leveraging advanced modeling and simulations to accelerate drug discovery

Medicinal
Chemistry

Designing and optimizing molecules for therapeutic success

Synthetic
Chemistry

Delivering innovative and scalable synthesis solutions for complex compounds

Analytical
Chemistry

Ensuring precision and quality through cutting-edge analytical techniques

Get in touch with us!

Computational Chemistry

SteerOn is a leading provider of computational chemistry services
combining computational chemistry expertise with extensive
database, offering a valuable resource for drug discovery
research. SteerOn assists in accelerating the drug discovery
pipeline, optimizing lead compounds, and providing insights into
the behaviour and properties of molecules and materials.
Whether it’s exploring new chemical entities or refining existing
compounds, SteerOn’s computational chemistry services can
contribute to the advancement of pharmaceutical research and
development.

SteerOn excels in structure-activity relationship (SAR) studies. SAR involves analysing the relationship between the structure of a molecule and its biological activity or property. By leveraging molecular docking studies, SteerOn can assess how molecules interact with target proteins or other biomolecules, helping to elucidate the mechanisms of action and predict the binding affinity of potential drug candidates.

Medicinal Chemistry

SteerOn’s Medicinal Chemistry Services specialize in the
Hit-to-Lead and Lead Optimization phases of drug
discovery. Our dedicated team actively participates in
designing and synthesizing novel molecules, leveraging SAR
insights and target information to accelerate the drug
discovery process. With expertise in computational
chemistry and a commitment to high-quality synthesis, we
strive to provide efficient and effective solutions for your
medicinal chemistry needs.

Accelerated Hit-to-Lead Phase

Our fast-track synthesis strategies enable rapid progression from hit identification to lead compound generation, saving valuable time in the drug discovery process.

SAR-Driven Design

By actively considering SAR insights and leveraging computational modeling, we assist in the rational design of lead compounds, increasing the likelihood of success in subsequent optimization steps.

High-Quality Synthesis

We prioritize the synthesis of fully characterized and high-quality compounds, ensuring reliability and reproducibility in your research.

Focused Library Synthesis

Our team specializes in designing and synthesizing targeted libraries of compounds tailored to address specific therapeutic areas or biological targets. With expertise in medicinal chemistry and a commitment to high-quality synthesis, we offer a comprehensive solution to accelerate your drug discovery efforts.

SAR Idea Generation

Our team leverages available target information and SAR data to generate innovative ideas for lead compounds. By analyzing structure-activity relationships, we help identify promising molecular scaffolds and design molecules with the desired pharmacological properties.

Fast-track Hit-to-Lead Synthesis

We take the lead in synthesizing fully characterized novel molecules to swiftly advance to the Hit-to-Lead stage. Leveraging our expertise in synthetic chemistry and extensive knowledge, we employ single- or multi-step synthesis strategies to efficiently generate compounds without compromising on quality.

Lead Optimization

Building on the initial hit compounds, we actively engage in lead optimization efforts. By employing SAR-driven approaches and utilizing computational modeling tools, we design analogs and derivatives with enhanced potency, selectivity, and pharmacokinetic properties. Our goal is to help you advance toward developing optimized lead candidates for further progression.

Comprehensive Characterization

Ensuring the highest quality of synthesized compounds is paramount. We use state-of-the-art analytical techniques to fully characterize novel molecules, providing you with detailed information on their chemical structure, purity, and physicochemical properties.

Focused Library Chemistry

Our team specializes in designing and synthesizing targeted libraries of compounds tailored to address specific therapeutic areas or biological targets. With expertise in medicinal chemistry and a commitment to high-quality synthesis, we offer a comprehensive solution to accelerate your drug discovery efforts.

01

SAR Idea Generation

Our team leverages available target information and SAR data to generate innovative ideas for lead compounds. By analyzing structure-activity relationships, we help identify promising molecular scaffolds and design molecules with the desired pharmacological properties.

02

Fast-track Hit-to-Lead Synthesis

We take the lead in synthesizing fully characterized novel molecules to swiftly advance to the Hit-to-Lead stage. Leveraging our expertise in synthetic chemistry and extensive knowledge, we employ single- or multi-step synthesis strategies to efficiently generate compounds without compromising on quality

03

Lead Optimization

Building on the initial hit compounds, we actively engage in lead optimization efforts. By employing SAR-driven approaches and utilizing computational modeling tools, we design analogs and derivatives with enhanced potency, selectivity, and pharmacokinetic properties. Our goal is to help you advance toward developing optimized lead candidates for further progression.

04

Comprehensive Characterization

Ensuring the highest quality of synthesized compounds is paramount. We use state-of-the-art analytical techniques to fully characterize novel molecules, providing you with detailed information on their chemical structure, purity, and physicochemical properties.

Building Blocks

Our team specializes in providing a diverse and high-quality collection of building blocks for medicinal chemistry research. With our comprehensive selection of compounds, we aim to facilitate and accelerate your drug discovery efforts by offering essential molecular components for synthesis and lead optimization.

Extensive Building Block Collection

We offer a vast catalogue of diverse and validated building blocks carefully curated for medicinal chemistry applications. Our collection includes a wide range of functional groups, core structures, and scaffolds to suit various synthetic needs.

Custom Building Block Synthesis

In addition to our extensive catalogue, we understand that specific projects may require unique or specialized building blocks. Our team is adept at synthesis and providing custom building blocks tailored to your project requirements, enabling you to access the necessary molecular components for your research.

Synthetic Chemistry

Synthetic chemistry lies at the heart of SteerOn’s
pioneering drug discovery efforts. By harnessing
innovative synthetic methods and strategies, our team
unlocks the potential of diverse chemical spaces,
optimizes lead compounds, and accelerates the
development of life-changing therapeutics. Through
integration with cutting-edge technologies and
interdisciplinary collaboration, we remain committed to
pushing the boundaries of drug discovery, transforming
patient care, and addressing unmet medical needs.

Synthetic Methodologies

Through innovative synthetic methodologies, our team creates unique compounds that hold the potential for breakthrough therapeutic applications

Advanced Multi-step Synthesis

Our synthetic chemists excel in designing efficient multi-step routes to synthesize complex molecules. By employing state-of-the-art techniques, such as retrosynthetic analysis and cascade reactions, we streamline the synthesis process, ensuring rapid access to target compounds

Diversity-Oriented Synthesis

SteerOn leverages Diversity-Oriented Synthesis (DOS) to expand chemical space for drug discovery. Through the utilization of diverse building blocks and innovative reaction methodologies, we create structurally diverse compound libraries, increasing the likelihood of identifying novel therapeutics

Combinatorial Chemistry

At SteerOn, we use combinatorial chemistry to create extensive compound libraries. By combining diverse building blocks and reaction conditions, we accelerate screening to identify potential drug candidates with varied biological activities.

Process development and scale-up capabilities

Process development and scale-up are vital components of the drug development journey at SteerOn. With a strong focus on delivering safe and effective therapeutics, our dedicated team of experts harnesses their scientific knowledge and technical prowess to optimize drug manufacturing processes. This note highlights the significance of process development and scale-up at SteerOn and showcases our commitment to ensuring efficient and high-quality drug development.

Safety and Efficacy

SteerOn places the utmost importance on developing robust and safe manufacturing processes. Our process development experts meticulously design and optimize production methods to ensure the highest levels of quality, purity, and efficacy for drug candidates

Cost Efficiency

Process development at SteerOn aims to streamline and optimize manufacturing processes, ensuring cost-effective production without compromising product quality. Our team of experts focuses on enhancing process efficiency, reducing waste, and optimizing resource utilization to drive cost savings

Quality by Design (QbD)

SteerOn embraces the principles of QbD throughout the process development phase. Our team identifies critical process parameters and attributes, conducts risk assessments, and designs robust control strategies to consistently deliver high-quality products.

Scale-Up Strategies

SteerOn’s process development team meticulously plans and strategizes the scale-up process, considering factors such as equipment selection, process transfer, and validation requirements. Thorough planning ensures a seamless transition from laboratoryscale to commercial-scale production

Safety and Efficacy

SteerOn places the utmost importance on developing robust and safe manufacturing processes. Our process development experts meticulously design and optimize production methods to ensure the highest levels of quality, purity, and efficacy for drug candidates

Cost Efficiency

Process development at SteerOn aims to streamline and optimize manufacturing processes, ensuring cost-effective production without compromising product quality. Our team of experts focuses on enhancing process efficiency, reducing waste, and optimizing resource utilization to drive cost savings

Quality by Design (QbD)

SteerOn embraces the principles of QbD throughout the process development phase. Our team identifies critical process parameters and attributes, conducts risk assessments, and designs robust control strategies to consistently deliver high-quality products.

Scale-Up Strategies

SteerOn’s process development team meticulously plans and strategizes the scale-up process, considering factors such as equipment selection, process transfer, and validation requirements. Thorough planning ensures a seamless transition from laboratoryscale to commercial-scale production

Analytical Chemistry

At SteerOn, we pride ourselves on delivering precise and reliable
analytical chemistry services, supported by state-of-the-art
infrastructure and a collaborative approach. Our analytical team
works in synergy with our chemistry experts to ensure every
compound we deliver meets the highest standards of quality and
integrity. We use advanced techniques and equipment for isolation,
purification, characterization, and structural elucidation, ensuring
accurate, reliable data for our clients’ projects.

Our Analytical Capabilities and Infrastructure:
  • HPLC with PDA and UV detectors for precise compound analysis.
  • LC-MS and GC-MS for comprehensive molecular characterization.
  • Preparative HPLC for high-throughput purification.
  • NMR spectrometers for structural elucidation of NCEs.
  • Karl Fischer equipment for accurate moisture content determination.
  • Lyophilizer and Vacuum ovens for drying and processing.
  • Electronic balances and pH meters for precision measurements.
  • Water purifying systems to maintain high standards of analytical processes.

Impurities and Metabolites

SteerOn specializes in identifying, characterizing, and synthesizing impurities and metabolites to support regulatory requirements and ensure drug safety. Our expertise spans N-nitroso impurities, process-related impurities, and stable isotopelabeled standards for comprehensive analysis.

Identification and Quantification

SteerOn employs advanced analytical techniques to identify and quantify impurities present in drug substances and drug products. Through extensive characterization, we ensure the accurate detection and measurement of impurities, including process-related impurities, degradation products, and residual solvents.

Metabolite Identification

SteerOn employs state-of-the-art techniques to identify and characterize metabolites formed during drug metabolism. Through in vitro and in vivo studies, we elucidate the metabolic pathways and profiles of drug candidates, providing critical insights into their safety, pharmacokinetics, and potential drug-drug interaction.
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About

SteerOn Research excels in setting PDE, ADE, and OEL for APIs, ensuring top safety in medicinal production at shared sites.

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  • World trade centre Unit No. 2201,A, 22nd Floor, Brigade Gateway, Malleshwaram (W), Bangalore-560055, Karnataka.
  • Our R&D site address:
    No. 35/6, 2nd floor, 1st main road, Peenya 2nd phase, Bangalore-560058,
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