Chemistry Services
Steeron Chemistry Services
Computational Chemistry
Medicinal Chemistry
SAR Idea Generation
Our team utilizes the available target information and SAR data to generate innovative ideas for lead compounds. By understanding the structure-activity relationships, we help you identify promising molecular scaffolds and design molecules with desired pharmacological properties.
Fast-track Hit-to-Lead Synthesis
We take the lead in synthesizing fully characterized novel molecules to reach the Hit-to-Lead stage swiftly. Leveraging our expertise in synthetic chemistry and an extensive knowledge base, we employ single or multistep synthesis strategies to generate compounds efficiently without compromising on quality.
Lead Optimization
Building upon the initial hit compounds, we actively engage in lead optimization efforts. By employing SAR-driven approaches and utilizing computational modeling tools, we design analogs and derivatives with improved potency, selectivity, and pharmacokinetic properties. Our goal is to help you progress towards developing optimized lead candidates for further development.
Comprehensive Characterization
Ensuring the highest quality of synthesized compounds is paramount. We employ state-of-the-art analytical techniques to fully characterize the novel molecules, providing you with detailed information on their chemical structure, purity, and physicochemical properties.
Accelerated Hit-to-Lead Phase
Our fast-track synthesis strategies enable rapid progression from hit identification to lead compound generation, saving valuable time in the drug discovery process.
SAR-Driven Design
By actively considering SAR ideas and leveraging computational modelling, we aid in the rational design of lead compounds, increasing the likelihood of success in subsequent optimization steps.
High-Quality Synthesis
We prioritize the synthesis of fully characterized and high-quality compounds, ensuring reliability and reproducibility in your research.
Focused Library Synthesis
SAR Idea Generation
Our team utilizes the available target information and SAR data to generate innovative ideas for lead compounds. By understanding the structure-activity relationships, we help you identify promising molecular scaffolds and design molecules with desired pharmacological properties.
Fast-track Hit-to-Lead Synthesis
We take the lead in synthesizing fully characterized novel molecules to reach the Hit-to-Lead stage swiftly. Leveraging our expertise in synthetic chemistry and an extensive knowledge base, we employ single or multistep synthesis strategies to generate compounds efficiently without compromising on quality.
Lead Optimization
Building upon the initial hit compounds, we actively engage in lead optimization efforts. By employing SAR-driven approaches and utilizing computational modeling tools, we design analogs and derivatives with improved potency, selectivity, and pharmacokinetic properties. Our goal is to help you progress towards developing optimized lead candidates for further development.
Comprehensive Characterization
Ensuring the highest quality of synthesized compounds is paramount. We employ state-of-the-art analytical techniques to fully characterize the novel molecules, providing you with detailed information on their chemical structure, purity, and physicochemical properties.
Building Blocks
Extensive Building Block Collection
We offer a vast catalogue of diverse and validated building blocks carefully curated for medicinal chemistry applications. Our collection includes a wide range of functional groups, core structures, and scaffolds to suit various synthetic needs.
Custom Building Block Synthesis
In addition to our extensive catalogue, we understand that specific projects may require unique or specialized building blocks. Our team is adept at synthesis and providing custom building blocks tailored to your project requirements, enabling you to access the necessary molecular components for your research.
Synthetic Chemistry
Through innovative synthetic methodologies,
Advanced Multi-step Synthesis
Diversity-Oriented Synthesis (DOS)
Combinatorial Chemistry
Analytical Chemistry
Process development and scale-up capabilities
Safety and Efficacy
TheraIndx places the utmost importance on developing robust and safe manufacturing processes. Our process development experts meticulously design and optimize production methods to ensure the highest levels of quality, purity, and efficacy for our drug candidates.
Cost Efficiency
Process development aims to streamline and optimize manufacturing processes, ensuring cost-effective production without compromising product quality. TheraIndx’s team of experts focuses on enhancing process efficiency, reducing waste, and optimizing resource utilization to drive cost savings.
Quality by Design (QbD)
TheraIndx embraces the principles of QbD throughout the process development phase. Our team identifies critical process parameters and attributes, conducts risk assessments, and designs robust control strategies to consistently deliver high-quality products.
Scale-Up Strategies
TheraIndx’s process development team meticulously plans and strategizes the scale-up process, considering factors such as equipment selection, process transfer, and validation requirements. Thorough planning ensures a seamless transition from laboratory-scale to commercial-scale production.
Impurities and Metabolites
Identification and Quantification
Steeron employs advanced analytical techniques to identify and quantify impurities present in drug substances and drug products. Through extensive characterization, we ensure the accurate detection and measurement of impurities, including process-related impurities, degradation products, and residual solvents.
Metabolite Identification
Steeron employs state-of-the-art techniques to identify and characterize metabolites formed during drug metabolism. Through in vitro and in vivo studies, we elucidate the metabolic pathways and profiles of drug candidates, providing critical insights into their safety, pharmacokinetics, and potential drug-drug interactions.
1
SAR
Idea Generation
2
Fast-track
Hit-to-Lead Synthesis
3
Lead
Optimization
4
Comprehensive Characterization
- Accelerated Hit-to-Lead Phase
- Our fast-track synthesis strategies enable rapid progression from hit identification to lead compound generation, saving valuable time in the drug discovery process.
- SAR-Driven Design
- By actively considering SAR ideas and leveraging computational modelling, we aid in the rational design of lead compounds, increasing the likelihood of success in subsequent optimization steps.
- High-Quality Synthesis
- We prioritize the synthesis of fully characterized and high-quality compounds, ensuring reliability and reproducibility in your research.
Focused Library Synthesis
1
Customized Library Design
2
Rational Scaffold Selection
3
Efficient and Scalable Synthesis
4
High-Quality Compound Production
Building Blocks
- Extensive Building Block Collection
- We offer a vast catalogue of diverse and validated building blocks carefully curated for medicinal chemistry applications. Our collection includes a wide range of functional groups, core structures, and scaffolds to suit various synthetic needs.
- Custom Building Block Synthesis
- In addition to our extensive catalogue, we understand that specific projects may require unique or specialized building blocks. Our team is adept at synthesis and providing custom building blocks tailored to your project requirements, enabling you to access the necessary molecular components for your research.
Synthetic chemistry
- Through innovative synthetic methodologies,
- our team creates unique compounds that hold the potential for breakthrough therapeutic applications.
- Advanced Multi-step Synthesis
- Our synthetic chemists are well-versed in designing efficient and practical multi-step synthetic routes to synthesize complex molecules. By employing state-of-the-art techniques, such as retrosynthetic analysis and cascade reactions, we streamline the synthesis process, ensuring the rapid access to target compounds.
- Diversity-Oriented Synthesis (DOS)
- Steeron embraces the power of DOS to expand the chemical space for drug discovery. Through the utilization of diverse building blocks and innovative reaction methodologies, we create structurally diverse compound libraries, increasing the likelihood of identifying novel therapeutics.
- Combinatorial Chemistry
- At Steeron we leverage combinatorial chemistry to generate extensive compound libraries. By combining different building blocks and reaction conditions, we accelerate the screening process, allowing for the identification of potential drug candidates with diverse biological activities.
- Analytical Chemistry
- Steeron synthetic chemists collaborate closely with analytical chemists to develop robust methods for compound purification, characterization, and analysis. By ensuring the purity and quality of synthesized compounds, we enhance the reliability of our research and support the elucidation of structure-activity relationships.
1
Safety and Efficacy
2
Cost Efficiency
3
Quality by Design (QbD)
4
Scale-Up Strategies
Impurities and Metabolites
- Identification and Quantification
- Steeron employs advanced analytical techniques to identify and quantify impurities present in drug substances and drug products. Through extensive characterization, we ensure the accurate detection and measurement of impurities, including process-related impurities, degradation products, and residual solvents.
- Metabolite Identification
- Steeron employs state-of-the-art techniques to identify and characterize metabolites formed during drug metabolism. Through in vitro and in vivo studies, we elucidate the metabolic pathways and profiles of drug candidates, providing critical insights into their safety, pharmacokinetics, and potential drug-drug interactions.
